About

I’m an ELLIS PhD student in Fabian Theis’s group at Helmholtz Munich. Previously, I did an internship in the Machine Learning Group at the Arc Institute, supervised by Yusuf Roohani. Before that, I completed my bachelor’s and master’s degrees in computational biology at the Technical University of Munich.

I’m interested in developing machine learning models to understand how biological systems respond to change. My main interests are perturbation modeling and sequence-to-function modeling: predicting how cells respond to genetic, chemical, or environmental perturbations, and how changes in DNA sequence affect gene regulation.

Publications

Single-cell differential expression analysis between conditions within nested settings.

Leon Hafner, Gregor Sturm, Sarah Lumpp, Mathias Drton, Markus List.
Briefings in Bioinformatics, 2025

Network medicine-based epistasis detection in complex diseases: ready for quantum computing.

Markus Hoffmann, [...], Leon Hafner, [...], Markus List, David B. Blumenthal.
Nucleic Acids Research, 2024